selenoproteins via genetic code expansion in mammalian cells

Selenoproteins, which contain the 21st amino acid selenocysteine, play roles in maintaining cellular redox homeostasis. Many open questions remain in the field of selenoprotein biology, including the functions of a …

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biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics

Here, we provide an overview of the¬†antibody¬†informatics tools applicable to the prediction of developability issues such as stability, aggregation, immunogenicity, and chemical degradation. We further evaluate the opportunities and challenges …

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